Antiviral strategies by Hans-Georg Kräusslich, Ralf Bartenschlager

By Hans-Georg Kräusslich, Ralf Bartenschlager

A the most important factor for antiviral treatment is the truth that all antiviral ingredients swiftly pick out for resistance; therefore, tracking and overcoming resistance has turn into a most vital medical paradigm of antiviral treatment. This demands wary use of antiviral medicinal drugs and implementation of mixture remedies. In parallel, efforts in drug discovery need to be persevered to improve compounds with novel mode-of-action and task opposed to resistant traces. This e-book stories the present prestige of antiviral treatment, from the roads to improvement of recent compounds to their medical use and value effectiveness. person chapters handle in additional aspect all to be had drug periods and description new techniques presently less than development.

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4 High-Throughput Screening for the Identification of New HCV Leads . . . . . 5 Cell-Based Assays to Predict Toxicity and Resistance Aspects . . . . . . . . . . . 6 Pharmacokinetic and Pharmacodynamic Aspects of Drug Development of Agents for the Treatment of HCV Infections . . . . . . . . . . . . . . . . . . . . . . . . 1 In Vitro Evaluation . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Preclinical In Vivo Testing .

26 27 28 32 32 35 37 37 39 40 40 41 42 42 43 43 44 46 Abstract Traditional methods for general drug discovery typically include evaluating random compound libraries for activity in relevant cell-free or cell-based assays. Success in antiviral development has emerged from the discovery of more focused libraries that provide clues about structure activity relationships. F. -G. Kr¨ausslich, R. F. Schinazi et al. is not enough. There are issues related to biology, toxicology, pharmacology, and metabolism that have to be addressed before a hit compound becomes nominated for clinical development.

1 In Vitro Evaluation . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Preclinical In Vivo Testing . . . . . . . . . . . . . . . . . . . . . . . 7 Physiological Factors that Influence Drug Delivery for HCV Drugs . . . . . . . . . 8 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . .

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