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48 36 • • 24 ~ Q. > w • 12 • I- w w C 0 0 10 15 20 25 Time (hours) after 360 ug/ cm2 application Figure 8. lg/cm2. 469 Human Skin Penetration and Irritation Potential ::cI 2000 N E .... 3 " 1600 . ;:; .. 0 Time (hours) after 125 mg/em2 dose Figure 9. , irritation. We measured the in vitro skin penetration of benzoic acid to compare damage to the barrier properties of pig skin caused by in vivo and in vitro exposure to an irritant material composed of a complex mixture of chemicals. 20 The irritant used in the study was liquid gun propellant (LP) which is being tested for use in a new artillery system.