Advances in Gene Delivery Systems by Kenya Kamimura; Takeshi Suda; Guisheng Zhang; Dexi Liu

By Kenya Kamimura; Takeshi Suda; Guisheng Zhang; Dexi Liu

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7:323. 10. , 1989, In vivo methods for percutaneous absorption measurements, in: Percutaneous Absorption Mechanisms-Methodology-Drug Delivery, 2nd ed. L. I. ), Dekker, New York, pp. 215-220. II. Klain, GJ. W. ), CRC, Boca Raton, pp. 247-266. 12. W. G. ), CRC, Boca Raton, pp. 81-109. 13. , 1991, Percutaneous penetration and skin retention of topically applied compounds: an in vitro - in vivo study. J. Pharm. , 80:526-532. 14. , 1984, Percutaneous penetration in the hairless dog, weanling pig and grafted athymic nude mouse: evaluation of models for predicting skin penetration in man.

15:149-156. 90. , 1987, Animal models for vesicant-induced injury, in: Praeeedings af the Vesicant Warkshap, February, 1987. S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD, 21010-5425. pp. 91-96. 91. pig skin, 1. Taxical. Cut. Ocular Taxieal. 8:309-319. 92. , 1991, Effects of nicotinamide on biochemical changes and microblistering induced by sulfur mustard in human skin organ cultures. Taxicol. Appl. Pharmacol. 107:439-449. 93. , 1990. Cutaneous toxicity of 2-chloroethyl methyl sulfide in isolated perfused porcine skin, Taxical.

48 36 • • 24 ~ Q. > w • 12 • I- w w C 0 0 10 15 20 25 Time (hours) after 360 ug/ cm2 application Figure 8. lg/cm2. 469 Human Skin Penetration and Irritation Potential ::cI 2000 N E .... 3 " 1600 . ;:; .. 0 Time (hours) after 125 mg/em2 dose Figure 9. , irritation. We measured the in vitro skin penetration of benzoic acid to compare damage to the barrier properties of pig skin caused by in vivo and in vitro exposure to an irritant material composed of a complex mixture of chemicals. 20 The irritant used in the study was liquid gun propellant (LP) which is being tested for use in a new artillery system.

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